Somatic complementation by fusion of two mutant cells and mixing of their cytoplasms occurs when the genetic defect of one fusion partner is cured by the functional gene product provided by the other. We have found that complementation of mutational defects in the network mediating stimulus‐induced commitment and sporulation of Physarum polycephalum may reflect time‐dependent changes in the signaling state of its molecular building blocks. Network perturbation by fusion of mutant plasmodial cells in different states of activation, and the time‐resolved (...) analysis of somatic complementation effects can be used to systematically probe network structure and dynamics. Time‐resolved somatic complementation quantitatively detects regulatory interactions between the functional modules of a network, independent of their biochemical composition or subcellular localization, and without being limited to direct physical interactions. BioEssays 25:950–960, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Recent studies from Western countries indicate significant levels of questionable research practices, but similar data from low and middle-income countries are limited. Our aims were to assess the prevalence of and attitudes regarding research misconduct among researchers in several universities in the Middle East and to identify factors that might account for our findings. We distributed an anonymous questionnaire to a convenience sample of investigators at several universities in Egypt, Lebanon, and Bahrain. Participants were asked to a) self-report their extent (...) of research misconducts, as well as their knowledge of colleagues engaging in similar research misconducts and b) provide their extent of agreement with certain attitudes about research misconduct. We used descriptive, bivariate, and multivariate logistic regression statistics to analyze the data. Data from 278 participants showed a high prevalence of misconduct, as 59.4% of our respondents self-reported to committing at least one misbehaviors and 74.5% reported having knowledge of any misbehaviors among any of their colleagues. The most common type of self-report misconduct was “circumventing research ethics regulations” followed by “fabrication and falsification”. A significant predictor of misconduct included a lack of “prior ethics training”. Scientific misconduct represents a significant issue in several universities in the Middle East. The demonstration that a lack of “prior ethics training” was a significant predictor of misconduct should lead to educational initiatives in research integrity. Further studies are needed to confirm whether our results can be generalized to other universities in the Middle East. (shrink)

Recently published data from the UK pointed out that the number of abortions performed under Ground E of the Abortion Act 1967, which allows abortion for foetal abnormalities, was far lower compare...

This article discusses a scenario of a teenager seeking medical assistance for infertility. Despite its apparent simplicity, the case poses a significant challenge to healthcare professionals. It requires consideration of maternal and child welfare and examination of the legitimate limits of doctors' role vis-à-vis the policy objective of reducing teenage pregnancy rate. The negative stereotypic representation of teenage pregnancy is an important confounding factor.

This work identifies the influence of chaos theory on fractional calculus by providing a theorem for the existence and stability of solution in fractional-order gyrostat model with the help of a fixed-point theorem. We modified an integer order gyrostat model consisting of three rotors into fractional order by attaching rotatory fuel-filled tank and provided an iterative scheme for our proposed model as a working rule of obtained analytical results. Moreover, this iterative scheme is injected into algorithms for a system of (...) integer order dynamical systems to observe Lyapunov exponents and a bifurcation diagram for our proposed fractional-order dynamical model. Furthermore, we obtained five equilibrium points, including four unstable spirals and one saddle node, using local dynamical analysis which acted as self-exciting attractors and a separatrix in a global domain. (shrink)

Our aim here is to show that an enigmatic text of Avicenna's Glosses, devoted to the problem of evil, takes on its full meaning in the light of the last chapter of the Šifā ' on De generatione et corruptione. We will see how Avicenna, deepening and developing a cosmological argument already present in the commentary of Alexander of Aphrodisias on the De generatione, ends up building most of his theodicy on the relative incommensurability of the different celestial periods. All (...) the problem of divine Justice is thus reinterpreted in terms of opposition between discrete and continuous. Finally we will show the importance that this development of Avicenna had in Western Christendom in the 14th century, and the complex relationship which Leibniz has with it in his recently edited reflections on the Great Year. (shrink)

Recruiting patients into clinical research is essential for the advancement of medical knowledge. However, when the physician undertaking the care of the patient is also responsible for recruitment into clinical research, a situation arises of an inter-role breach of confidentiality which is distinguishable from other conflicts of interest. Such discord arises as the physician utilizes confidential information obtained within the therapeutic relationship beyond its primary objective, and safeguards ought to be observed in order to avert this important, and generally overlooked, (...) problem. The moral worth of the pledge of confidentiality is based not on its innate value but on its being a promise on which subsequent interactions and disclosures are founded. Within the patient-doctor interaction, confidentiality is an important facet of the promised fidelity and, as such, a loose interpretation of the notion threatens the essence of the relationship, and any violation thereof requires compelling moral justification. To avoid conflict, patients' confidential information ought not be used for the purpose of recruitment, which needs to be undertaken through general education and non-directed appeals, and a preliminary consent to be approached for research should be obtained from the patient prior to her being identified as a suitable research subject. Securing this prior consent would avoid one source of potential, albeit unintended, coercion. (shrink)

The present study aims at explaining how the Relevance Theory could be a viable approach to weigh up the main functions of some concessive Pragmatic Operators in Jordanian Arabic at the production and interpretation levels. A sample of twenty-two speeches delivered by members of the Jordanian Parliament the 16th was randomly selected for scrutiny. Three POs detected in their speeches were analyzed at the token level in light of three elementary RT assumptions about discourse connectives in general, namely connectivity, the (...) conceptual-procedural distinction, and monosemy. The major finding of this study was that concessive POs, as a subset of contrastives, are used to optimize relevance: highlight certain dimensions and/or suppress others of the scenario to the background. However, the point of departure from possibly all previous treatments is that the speakers, as politicians, still used them more strategically because total ambiguity resolution should not be a viable alternative in social settings laden with politics. (shrink)

Machine generated contents note: 1. Introduction; 2. International law and postcolonial Africa; 3. Violence and conflicts in Africa; 4. Institutional responses to conflicts; 5. Genesis of the African Union; 6. Structures and philosophy of the African Union; 7. The African Union's peacebuilding travails in Burundi; 8. The African Union and peace initiatives in post-state Somalia; 9. Towards an African Union philosophy on peacebuilding?.

The series Commentaria in Aristotelem Graeca et Byzantina: Series academica is published by the Berlin-Brandenburg Academy of Sciences, and functions as a complement to the series Commentaria in Aristotelem Graeca et Byzantina: Sources and Studies. The editions and source collections of the Series academica provide a basis for research on Byzantine philosophy and education and on the lasting impact of peripatetic philosophy in the Greek middle ages. The series succeeds to the Commentaria in Aristotelem Graeca directed by Hermann Diels and (...) published by the Royal Prussian Academy of Sciences. The publication schedule of the series includes editions of commentaries by Alexander of Aphrodisias, Simplicius, John Philoponus, Michael of Ephesus, Nicephorus Blemmydes, George Pachymeres, Theodore Metochites, George Scholarius, and Bessarion. The series is also open for preliminary studies and companion volumes. https://www.degruyter.com/view/serial/CAGB-B. (shrink)

Guilt and fear today have developed an unexpected quality: they contribute powerfully to the survival of humanity. The feeling of guilt proceeds from an elementary awareness: although the unequaled progress of science and technology in the twentieth century has undoubtedly ameliorated the conditions of human life, it also has given rise to an infernal logic of genocide and crimes against humanity, in which almost all nations, directly or indirectly, have participated and participate still. This awareness is joined to another, which (...) is itself accompanied by a primordial fear: for the first time in history, science and technology have endowed humanity with the power to destroy itself and the planet, without furnishing humans with the means of escaping their destined role as sorcerer's apprentice, for no science can tell us what to do with science. It is this double feeling of guilt and fear that pushes contemporary man to search feverishly for ethical foundations capable of furnishing discreet regulatory principles to underpin decisions and actions. From the point of view of contemporary humanity, ethics must be able to confer meaning and perspective on an existence which apparently has neither: “Now,” writes Hans Jonas, “we shiver in the nakedness of nihilism in which near-omnipotence is paired with near-emptiness, greatest capacity with knowing least for what ends to use it.”. (shrink)

Ten years ago, an issue of the journal L'Homme et la Société was entitled “La Mode des identités.” Most of the articles were about cultural identity, but the basic thrust of the work was “a critique of the ‘fashion’ of identity calling into question the validity of a notion as striking as it is uncertain.” Recently, a special issue of the journal Sciences Humaines, entitled “Identité et identités,” dealt with personal, familial, social, professional identities and only spoke of cultural identity (...) marginally and in a roundabout way. Finally, in a manual of Sociologie politique published by the Presses Universitaires de France, the author takes to task the notion of ethnicity inherent to cultural identity and pushes the critique of the ethnic group to the point of negating its objective existence. Must we think then that the notion of cultural identity is henceforth obsolete, that it has lost all pertinence? (shrink)

Les Enjeux du discours philosophique pour l'Afrique est consacré non pas à l'ethnophilosophie, mais à l'orientation africaine en philosophie ou de la philosophie qui se déploie sous des talents et plumes aussi riches que contradictoires : Placide Tempels, John Mbiti et Alexis Kagame, Nkrumah, Paulin Hountondji, Eboussi Boulaga, Marcien Towa, Niamkey Koffi, Abdou Touré, Yacouba Konaté, Jean-Godefroy Bidima, Augustin Dibi, etc. Ce n'est pas un ouvrage de "philosophie africaine", si l'adjonction de l'épithète africaine devrait trahir la philosophie qui, depuis Platon, (...) est universelle et ses "vérités" indépendantes des limitations géographiques, raciales et nationales. L'Afrique a, certes, ses limites dans tous les sens du substantif, mais la vocation trans-territoriale du discours philosophique demeure. Elle s'incarne dans le pari que prend Les enjeux du discours philosophique pour l'Afrique de redire, dans les termes de la théorie critique, de l'espace africain ce qu'il garderait sous un double voile d'ignorance et d'opulence. Il s'agit des défis rapportés aux langues, aux savoirs et aux orphelins du savoir, aux pouvoirs et aux orphelins du pouvoir, aux sous-développements et aux démocraties du même ordre, aux idéologies, etc. (shrink)

This paper proposes a conceptual framework for understanding the implementation process of a complex intervention concerned with professional role change. The proposed framework holds that the intervention must address three interacting systems (socio-cultural, educational and disciplinary) through which a health professional role is evolved. Each system is operationalized by four dimensions (values, methods, actors and targets). As for the implementation, the framework posits that it can be analyzed, by depicting the barriers and facilitators located within the dimensions of the three (...) interacting systems and within the intervention involved in the process through using the “menu of constructs” approach suggested by the Consolidated Framework for Implementation Research (CFIR). The implications of this framework, on theoretical research and practical levels, are reviewed. (shrink)

Ethics issues in the areas of science, technology and medicine have emerged during the last few decades. Many countries have responded by establishing ethics committees at the national level. Identification of National Ethics Committees (NECs) in the Eastern Mediterranean (EM) region and the extent of their functions and capacity would be helpful in developing capacity building programs that address the needs of these committees. Accordingly, we conducted a survey to determine the characteristics of existing NECs in the EM region.

In the recent years, an alarming rise in the incidence of cyber attacks has made cyber security a major concern for nations across the globe. Given the current volatile socio-political environment and the massive increase in the incidence of terrorism, it is imperative that government agencies rapidly realize the possibility of cyber space exploitation by terrorist organizations and state players to disrupt the normal way of life. The threat level of cyber terrorism has never been as high as it is (...) today, and this has created a lot of insecurity and fear. This study has focused on different aspects of cyber attacks and explored the reasons behind their increasing popularity among the terrorist organizations and state players. This study proposes an empirical model that can be used to estimate the risk levels associated with different types of cyber attacks and thereby provide a road map to conceptualize and formulate highly effective counter measures and cyber security policies. (shrink)

La diffusion d'Alexandre d'Aphrodise, en raison de la qualité inégalée de son exégèse d'Aristote, est celle des textes vivants. Simplicius est plus érudit, Philopon plus critique, Averroès plus savant. Mais Alexandre possédait un art de la synthèse entre l'analyse philologique de la lettre et la saisie de l'orientation générale d'un texte, qui fait de lui l'Exégète par excellence. On comprend, dans ces conditions, que sa transmission ne soit pas le relais linéaire d'un ‘‘témoin” figé. Citons aussi bien le recours extensif (...) de Simplicius, au VI e siècle, à ses commentaires physiques que la renaissance philosophique des IX e –X e siècles en terre d’Islam, qui s'accompagne d'un mouvement massif de traduction de textes alexandriques. Or s'il apparaît de plus en plus clairement que c'est la nécessité de bâtir une ontologie du sensible aristotélicienne, subordonnée à l'ontologie platonicienne des Formes divines, qui a poussé le ‘‘platonicien” Simplicius à puiser dans les commentaires de son prédécesseur, on ne s’est pas encore assez interrogé sur le sens de l'intérêt aigu des philosophes islamiques pour Alexandre. Pourquoi, par exemple, alors que les Byzantins, quand ils ont eu le choix entre Alexandre et Simplicius, ont choisi Simplicius, les Arabes se sont-ils systématiquement décidés pour Alexandre? (shrink)

This book is the first study of the ontological system of Alexander of Aphrodisias (floruit c. 200 AD), famous for his commentaries on the works of Aristotle.

Objective To determine the attitudes of Egyptian patients regarding their participation in research and with the collection, storage and future use of blood samples for research purposes. Design Cross-sectional survey. Study population Adult Egyptian patients (n=600) at rural and urban hospitals and clinics. Results Less than half of the study population (44.3%) felt that informed consent forms should provide research participants the option to have their blood samples stored for future research. Of these participants, 39.9% thought that consent forms should (...) include the option that future research be restricted to the illness being studied. A slight majority (66.2%) would donate their samples for future genetic research. Respondents were more favourable towards having their blood samples exported to other Arab countries (62.0%) compared with countries in Europe (41.8%, p<0.001) and to the USA (37.2%, p<0.001). Conclusions This study shows that many individuals do not favour the donation of a blood sample for future research. Of those who do approve of such future research, many favour a consent model that includes an option restricting the future research to the illness being studied. Also, many Egyptians were hesitant to have their blood samples donated for genetic research or exported out of the Arab region to the USA and European countries. Further qualitative research should be performed to determine the underlying reasons for many of our results. (shrink)

Source: Author: Marwan Kadhim Mohammed, Wan Roselezam Wan Yahya Martin Amis's manipulation of the patriarchal concept of power is a notable indication of his transgressive attitudes that raise remarkable questions about the human identity. Transgressing power investigates the violation of the normal and familiar trends of literature in order to circulate a new discourse by which a new identity is reframed. Hence, the study of power in Martin Amis's novels, as an important technique of identity re-definition, is not taken (...) into consideration in the light of Foucault's theory of power. The objective of this study is to examine the role applied by transgression as a technique of subverting the common discourse of power in the field of identity re-formation. The study investigates the concept of power manipulated in Amis's Money to define the identity of the 'New Man'. Accordingly, the Foucauldian theory of power is taken as a framework of this study. The study reveals a conclusion in which the transgressive aspects of power are effectively utilized by Amis to re-define the identity of his protagonist in the novel. Although John Self-has finally lost his name and fortune, which are necessary demands to define one's self-in the patriarchal society, he finds his own new identity away from the materialistic norms of the common discourse. ]]>. (shrink)

Should face transplants be undertaken? This article examines the ethical problems involved from the perspective of the recipient, looking particularly at the question of identity, the donor and the donor’s family, and the disfigured community and society more generally. Concern is expressed that full face transplants are going ahead.

Der heute verlorene Kommentar von Alexander aus Aphrodisias zur Physik des Aristoteles ist eines der wichtigsten Werke der Antike: beeinflusste er doch als Quelle sowohl die griechischen Kommentatoren des Aristoteles als auch - vermittelt durch die Araber - die Philosophie des Mittelalters. Die in dieser Ausgabe pr+sentierte Erstedition und Untersuchung der nahezu 700 byzantinischen Scholien, die erst j8ngst entdeckt wurden, erlauben eine genauere Rekonstruktion der physikalischen Lehren Alexanders und tragen zugleich zum besseren Verst+ndnis der Geschichte des Aristotelismus und der vorklassischen (...) Physik bei. (shrink)

The reference to Albinus in a refutation of Bardesanes († c. 222) by Ephrem the Syrian († 373) is not unknown to modern commentators. This text, edited and translated into English since the beginning of the twentieth century, is regularly mentioned, albeit rather cursorily, by scholars of Middle Platonism. Although much has been clarified between the first publication of the book just over a century ago and the present day, the following pages aim to continue the exploration. The aim will (...) be to better understand what has so far remained unnoticed: the dependence of Albinus’ work on Posidonius on three crucial points: (1) his classification of incorporeals, (2) his doctrine of comprehensive representation, and (3) the deep relationship between (1) and (2). (shrink)

Sustainable development goals are aligning marketing innovations to meet sustainability interventions. Recently, marketing has evolved to incorporate sustainability in outreach objectives. Heightened literature on the interplay between sustainability, innovations, and marketing demands a holistic understanding to guide future research direction. The current review bridges the research gap using quantitative performance analysis and qualitative intellectual structure analysis. The thematic and content analysis points towards permeating sustainability focus across the business verticals and value chain for differentiated brand positioning and sustainability-based competitive advantage. (...) The emergent conceptual framework underpins the moderated-mediation role of sustainability and economic enablers with marketing initiatives to promote business innovations beneficial to all stakeholders. The sustainability-aligned innovations in products and processes reflect in gaining cost advantage, revenue generation, access to newer markets, and differentiation. It can be inferred from the study that sustainability and conducive marketing strategies can co-create value across the value chain, providing tangible and non-tangible corporate payoffs. This cross-section in the research domain calls for environmental and business focus at the micro and macro levels, supported by pro-business strategies, system efficiencies, productivity, and technological changes in synergy with the societal landscape. The findings discern strategic directions for practitioners to chart out an organizational portfolio centered around marketing innovations to create business value for the shareholders and sustainability value for the stakeholders, ecosystem, and society. The conceptual framework can help academicians comprehend the business model around sustainability, innovations, and marketing. The evolutionary mapping of the research domain can be used to discern corporate or macro-level policies and transcend reforms aligned to the dynamic market/stakeholder expectations. (shrink)

The present article aims to show that the treatise On the Harmonization of the Opinions of the Two Sages the Divine Plato and Aristotle cannot have been written by al-FbwillryAdAdrr in the field of cosmology, for theological reasons.

The Druze movement originated at the beginning of the eleventh century and developed out of the Ismā'īlī faction of Shī'ī Islām. Founded by the Ismā'īlī Ḥamza ibn 'Alī, the Tawḥīd is a philosophical and spiritual path that incorporates the fundamentals of Islam, Christianity, and Judaism referred to in the Qur'ān, together with the ancient philosophies of Pythagoras, Plato, Aristotle, Plotinus, and others. It is a synthesis and a unification of the most contradictory thoughts, a synthesis that leads to the real (...) Tawḥīd or "third course".The specificity of the Tawḥīd consists in establishing a bridge between monotheism and non-dualism. To say that God is One does not merely mean... (shrink)

In this article, we use the principlist approach to identify, analyse and attempt to solve the ethical problem raised by a pregnant woman's request for cesarean delivery in absence of medical indications.We use two different types of premises: factual (facts about cesarean delivery and specifically attitudes of obstetricians as derived from the EUROBS European study) and value premises (principles of beneficence and non-maleficence, respect for autonomy and justice).Beneficence/non-maleficence entails physicians' responsibility to minimise harms and maximise benefits. Avoiding its inherent risks (...) makes a prima facie case against cesarean section without medical indication. However, as vaginal delivery can have unintended consequences, there is a need to balance the somewhat dissimilar risks and benefits. The principle of autonomy poses a challenge in case of disagreement between the pregnant woman and the physician. Improved communication aimed to enable better informed choice may overcome some instances of disagreement. The principle of justice prohibits unfair discrimination, and broadly favours optimising resource utilisation.Available evidence supports vaginal birth in uncomplicated term pregnancies as the standard of care. The principlist approach offered a useful framework for ethical analysis of cesarean delivery on maternal request, identified the rights and duties of those involved, and helped reach a conclusion, although conflict at the individual level may remain challenging. (shrink)

Parochial altruism is manifested in the most violent of conflicts. Although it makes evolutionary sense for kin, many non-kin groups also behave parochially altruistically in response to threat from out-groups. It is possible that such non-kin groups share a sense of “fictive” kinship which encourages them to behave parochially altruistically for each other’s benefit. Our findings show that individuals not directly involved in a conflict approved of parochial altruism enacted by an in-group against an out-group more when the out-group posed (...) a threat to the in-group; however, this effect wasgreaterwhen the in-group members expressed fictive kinship by addressing each other using kinship metaphors such as “brothers.” Furthermore, although males approved of parochial altruism more than females, as the male warrior hypothesis would suggest, the effects of threat and kinship metaphor on approval of parochial altruism applied to both genders. These findings were replicated in an honour and non-honour culture. (shrink)

This article aims to unravel the doctrine of the “sign from the manifest to the hidden” of Abū Hāšim al-Ğubbāʾī. It shows that Abū Hāšim tended to interpret this sign as an inference, of which he recognized two main types: Type-1 proceeds by analytical deduction of concepts by neutralizing the conditions of their realization, i. e. their ontological basis. This is, typically, the procedure most directly consonant with Abū Hāšim's modal ontology. Type-2 exhibits the same causal relationship at the known (...) and unknown levels and considers causality at the known level to be itself the cause of causality at the unknown level. This partition was completely new in philosophy and kalām at the time of Abū Hāšim, but it is foreshadowed in al-Ḫwārizmī’s Algebra. In this book, al-Ḫwārizmī distinguishes between proof “by cause”, which consists in transferring a certain geometric deduction to algebra, and proof “by expression”, which operates directly on algebraic expressions, which it reduces analytically. A text by Abū Hāšim devoted to human knowledge that seems to refer to the work of al-Ḫwārizmī suggests, finally, that the close parallel between al-Ḫwārizmī’s doctrine of proof and Abū Hāšim's doctrine of the sign may not be a mere coincidence. Two appendices have been added. The first deals with al-Fārābī’s reading of Abū Hāšim's theory of inference. The second, based on all available data, establishes for the first time the correct and precise dates of Abū Hāšim's life. (shrink)

Le fr. 2 de Boéthos de Sidon est transmis par deux commentateurs alexandrins des Catégories d'Aristote. En voici le texte grec:[2a] Ioannes Philoponus, In Aristotelis Categorias commentarium, 5.15-20Τρίτον ἦν ἐφεξῆς κεφάλαιον τὸ πόθεν δεῖ ἄρχεσθαι τῶν Ἀριστοτελι-[16]κῶν συγγραμμάτων. Βόηθος μὲν οὖν φησιν ὁ Σιδώνιος δεῖν ἀπὸ τῆς [17] φυσικῆς ἄρχεσθαι πραγματείας ἅτε ἡμῖν συνηθεστέρας καὶ γνωρίμου, δεῖν [18] δὲ ἀεὶ ἀπὸ τῶν σαφεστέρων ἄρχεσθαι καὶ γνωρίμων. ὁ δὲ τούτου δι-[19]δάσκαλος Ἀνδρόνικος ὁ Ῥόδιος ἀκριβέστερον ἐξετάζων ἔλεγε χρῆναι πρό-[20]τερον ἀπὸ τῆς λογικῆς (...) ἄρχεσθαι, ἥτις περὶ τὴν ἀπόδειξιν καταγίνεται. (shrink)

Ces deux ouvrages qui font la matière de ce volume se complètent parfaitement, c'est pourquoi ils paraissent sous le même titre. L'auteur analyse dans Esquisse d'une esthétique l'activité gratuite de l'artiste. Le procès de la conscience dénonce d'un côté la conscience de l'autre, reconnaît que les religions et les philosophies ne sont que des issues qui permettent de combler le vide d'être que la conscience a creusé en nous.